abstract：PURPOSE:To assess the efficacy of acetylleucine to improve or stop an attack of vertigo and dizziness (vertigo/dizziness). METHODS:Systematic review by 2 independent reviewers. Consultation of the Medline, Cochrane and ClinicalTrials.gov databases until September 2018. Keywords used: Acetylleucine, Tanganil®, Acetyl-D...

journal_title：European journal of clinical pharmacology

authors： Vanderkam P,Blanchard C,Naudet F,Pouchain D,Vaillant Roussel H,Perault-Pochat MC,Jaafari N,Boussageon R

更新日期：2019-05-01 00:00:00

abstract：AIMS:The goal of this study was to analyze persistence and the treatment-free interval in patients being prescribed biological drugs in rheumatology practices in Germany. METHODS:Patients who received a first prescription of biological drugs between 2008 and 2016 in 21 rheumatologists in Germany were included in this ...

journal_title：European journal of clinical pharmacology

authors： Kostev K,Jacob L

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:Lithium (Li), the first-line treatment of bipolar disorder, was first developed as an immediate-release form with a routine therapeutic drug monitoring 12 h after the last dose. In Europe, the most commonly prescribed form is a sustained release (srLi). Yet no pharmacokinetics (PK) study has been published of s...

journal_title：European journal of clinical pharmacology

authors： Couffignal C,Bertrand J,Sportiche S,Jarroir M,El Balkhi S,Djebrani-Oussedik N,Poupon J,Declèves X,Mentré F,Bellivier F

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:In the management of melanoma, BRAF inhibitors yield fast disease control; however, the duration of response does not last very long. Ipilimumab-an anti-CTLA4 antibody on the other hand-provides longer-lasting results of treatment but achieves less favorable responses. The aim of this study was to assess the ef...

journal_title：European journal of clinical pharmacology

authors： Polkowska M,Ekk-Cierniakowski P,Czepielewska E,Kozłowska-Wojciechowska M

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:Older people with advanced frailty are among the highest consumers of medications. When life expectancy is limited, some of these medications are likely to be inappropriate. The aim of this study was to compare STOPPFrail, a concise, easy-to-use, deprescribing tool based on explicit criteria, with gold standard...

journal_title：European journal of clinical pharmacology

authors： Curtin D,Dukelow T,James K,O'Donnell D,O'Mahony D,Gallagher P

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of this randomized, placebo-controlled, double-blind study was to investigate the preventive effect of topical administration of atorvastatin (ATV) on the acute radiation-induced skin toxicity in patients with breast cancer. PATIENTS AND METHODS:Seventy breast cancer patients were ra...

journal_title：European journal of clinical pharmacology

authors： Ghasemi A,Ghashghai Z,Akbari J,Yazdani-Charati J,Salehifar E,Hosseinimehr SJ

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:Pharmacodynamic studies of naloxone require opioid agonism. Steady state condition may be achieved by remifentanil TCI (target controlled infusion). Opioid agonism can be measured by pupillometry. It is not known whether there are arteriovenous concentration differences for naloxone. The aim was thus to further...

journal_title：European journal of clinical pharmacology

authors： Tylleskar I,Skulberg AK,Skarra S,Nilsen T,Dale O

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:Tamsulosin is one of the most potent drugs currently available to treat benign prostatic hyperplasia. Cytochrome P450 (CYP) 2D6 and CYP3A are the two major enzymes responsible for tamsulosin metabolism. The purpose of this study was to evaluate the effects of CYP2D6 and CYP3A5 genetic polymorphisms on the pharm...

journal_title：European journal of clinical pharmacology

authors： Kim KA,Park IB,Park JY

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:Ilaprazole, the latest proton pump inhibitor, can be used with clarithromycin and amoxicillin as a triple therapy regimen for eradicating Helicobacter pylori. The aim of this study was to evaluate pharmacokinetic drug interactions and safety profiles after coadministration of clarithromycin, amoxicillin, and il...

journal_title：European journal of clinical pharmacology

authors： Jin BH,Yoo BW,Park J,Kim JH,Lee JY,Shin JS,Park MS

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:To aid prescribers in assessing a patient's risk for statin-induced myopathy (SIM), we performed a comprehensive review of currently known risk factors and calculated aggregated odds ratios for each risk factor through a meta-analysis. METHODS:This meta-analysis was done through four phases: (1) Identification...

journal_title：European journal of clinical pharmacology

authors： Nguyen KA,Li L,Lu D,Yazdanparast A,Wang L,Kreutz RP,Whipple EC,Schleyer TK

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:The present study was carried out in order to assess the effects of chronic administration of flunitrazepam (as an oral hypnotic) on 24-h blood pressure (BP) and heart rate (HR) in healthy young adults. MATERIALS AND METHODS:Following a 2-week placebo run-in period, 28 healthy volunteers (13 males and 15 femal...

journal_title：European journal of clinical pharmacology

authors： Bosone D,Fogari R,Zoppi A,D'Angelo A,Ghiotto N,Perini G,Ramusino MC,Costa A

更新日期：2018-08-01 00:00:00

abstract：INTRODUCTION:This study compared the characteristics of new human drugs approved by the Food and Drug Administration (FDA), the European Medicine Agency (EMA), and Swissmedic (SMC) in the period 2007 to 2016. METHODS:The list of new drugs and therapeutic biologics approved by the FDA, the EMA, and SMC in the period 20...

journal_title：European journal of clinical pharmacology

authors： Zeukeng MJ,Seoane-Vazquez E,Bonnabry P

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:The objective of this work was to develop a population pharmacokinetic model for a prolonged-release granule formulation of valproic acid (VPA) in children with epilepsy and to determine the doses providing a VPA trough concentration (Ctrough) within the target range (50-100 mg/L). METHODS:Ninety-eight childre...

journal_title：European journal of clinical pharmacology

authors： Rodrigues C,Chhun S,Chiron C,Dulac O,Rey E,Pons G,Jullien V

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:Sitagliptin, a dipeptidyl peptidase (DPP)-IV inhibitor approved for the treatment of type 2 diabetes, is reported to be more efficacious in Indian patients than non-Indian patient population. The objective of the study was to evaluate pharmacokinetic and pharmacodynamic (PK/PD) parameters of single-dose sitagli...

journal_title：European journal of clinical pharmacology

authors： Sangle GV,Patil M,Deshmukh NJ,Shengule SA,Kamble S,Vuppalavanchu KK,Kale S,Baig MLA,Singh G,Shaikh J,Tripathi J,Aravindababu P

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:Older people with several chronic conditions require multiple drugs from different classes to be adequately treated. This study aims to: (i) measure medication adherence across multiple conditions and therapeutic drug groups in older community-dwelling patients, and (ii) examine the effect of multimorbidity on ...

journal_title：European journal of clinical pharmacology

authors： Kim S,Bennett K,Wallace E,Fahey T,Cahir C

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:Methylenedioxymethamphetamine (MDMA, ecstasy) is used recreationally and frequently leads to sympathomimetic toxicity. MDMA produces cardiovascular and subjective stimulant effects that were shown to partially depend on the norepinephrine transporter (NET)-mediated release of norepinephrine and stimulation of α...

journal_title：European journal of clinical pharmacology

authors： Vizeli P,Meyer Zu Schwabedissen HE,Liechti ME

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:To investigate associations between antidepressant use patterns and risk of fatal and non-fatal suicidal behaviours in older adults who initiated antidepressant therapy. METHOD:A national population-based cohort study conducted among Swedish residents aged ≥ 75 years who initiated antidepressant treatment. Pat...

journal_title：European journal of clinical pharmacology

authors： Hedna K,Andersson Sundell K,Hamidi A,Skoog I,Gustavsson S,Waern M

更新日期：2018-02-01 00:00:00

abstract：:Since 1988, the German Embryotox institute combines individual counselling of pregnant women and their health care providers (HCP) with research on drug safety in pregnancy. In addition, Embryotox offers web-based information which covers the most important and most frequently requested pharmaceutical substances. In c...

journal_title：European journal of clinical pharmacology

authors： Dathe K,Schaefer C

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Sequential and concomitant therapies are two innovative therapies for Helicobacter pylori (H. pylori) eradication. However, the comparative efficacy and safety of these treatments are controversial. Therefore, we aimed to conduct an updated systematic review and meta-analysis of studies that compared these t...

journal_title：European journal of clinical pharmacology

authors： Wang Y,Zhao R,Wang B,Zhao Q,Li Z,Zhu-Ge L,Yin W,Xie Y

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:The Drug Burden Index (DBI) is a tool to quantify the anticholinergic and sedative load of drugs. Establishing functional correlates of the DBI could optimize drug prescribing in patients with dementia. In this cross-sectional study, we determined the relationship between DBI and cognitive and physical function...

journal_title：European journal of clinical pharmacology

authors： Sanders LMJ,Hortobágyi T,van Staveren G,Taxis K,Boersma F,Klein HC,Bossers WJR,Blankevoort CG,Scherder EJA,Van der Zee EA,van Heuvelen MJG

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Tamoxifen is one of the cornerstones of endocrine therapy for breast cancer. Recently, the decreased activity CYP3A4*22 allele and the loss of function CYP3A5*3 allele have been described as potential factors that could help to explain the inter-patient variability in tamoxifen metabolism. The aim of this st...

journal_title：European journal of clinical pharmacology

authors： Sanchez Spitman AB,Moes DJAR,Gelderblom H,Dezentje VO,Swen JJ,Guchelaar HJ

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to systematically review evidence regarding the association between regimen complexity and adherence. METHODS:Articles were searched in MEDLINE, LILACS, Cochrane, CINAHL, PsycINFO and references of included studies. Search terms included medication regimen complexity, medication a...

journal_title：European journal of clinical pharmacology

authors： Pantuzza LL,Ceccato MDGB,Silveira MR,Junqueira LMR,Reis AMM

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:The purpose of this study is to investigate whether there is an association between anticholinergic burden and mortality or rehospitalization in older adults discharged from hospital. METHODS:Prospective multicenter cohort study carried out with patients aged 65 and older discharged from seven acute care hospi...

journal_title：European journal of clinical pharmacology

authors： Gutiérrez-Valencia M,Martínez-Velilla N,Vetrano DL,Corsonello A,Lattanzio F,Ladrón-Arana S,Onder G

更新日期：2017-11-01 00:00:00

abstract：:In the 3rd paragraph and 2nd line of the Conclusion section the correct sentence should be: It is now important to encourage policy and decision makers to facilitate and accommodate future linkage of data. ...

journal_title：European journal of clinical pharmacology

authors： Sinnott SJ,Bennett K,Cahir C

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate the influence of patient characteristics such as age and stroke and bleeding risks on decisions for antithrombotic treatment in patients with atrial fibrillation (AF). METHODS:This was a retrospective, population-based study including AF patients initiated with eith...

journal_title：European journal of clinical pharmacology

authors： Komen J,Forslund T,Hjemdahl P,Wettermark B

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:The study aimed to test the hypothesis that hospital electronic prescribing and medicine administration system (HEPMA) implementation impacted patient discharge letter quality, nature and frequency of prescribing errors. METHOD:A quasi experimental before and after retrospective case note review was conducted ...

journal_title：European journal of clinical pharmacology

authors： Mills PR,Weidmann AE,Stewart D

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:The use of surgical antibiotic prophylaxis (SAP) in children is poorly characterized. Our aim was to evaluate the effectiveness of a quality improvement (QI) intervention targeting SAP in children, by means of a multicenter prospective intervention study, with a before and after design. METHODS:We prospectivel...

journal_title：European journal of clinical pharmacology

authors： Ciofi Degli Atti M,Alegiani SS,Raschetti R,Arace P,Giusti A,Spiazzi R,Raponi M,APACHE Study Group.

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the contributions of non-genetic and genetic factors on the variability of stable warfarin doses in Thai patients. METHODS:A total of 250 Thai patients with stable warfarin doses were enrolled in the study. Demographics and clinical data, e.g., age, body mass index, ind...

journal_title：European journal of clinical pharmacology

authors： Wattanachai N,Kaewmoongkun S,Pussadhamma B,Makarawate P,Wongvipaporn C,Kiatchoosakun S,Vannaprasaht S,Tassaneeyakul W

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:There are concerns regarding appropriate use of antibiotics in dentistry practice. Data on dental antibiotic prescribing patterns by dentists is relatively limited. This nationwide study aimed to examine dentists' antibiotic prescriptions in a diagnosis-based manner in Turkey. METHODS:This retrospective study ...

journal_title：European journal of clinical pharmacology

authors： Koyuncuoglu CZ,Aydin M,Kirmizi NI,Aydin V,Aksoy M,Isli F,Akici A

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:We proposed a statistical criterion to detect drug-drug interactions causing adverse drug reactions in spontaneous reporting systems. METHODS:The used criterion quantitatively measures the discrepancy between the observed and expected number of adverse events via chi-square statistics. We compared the performa...

journal_title：European journal of clinical pharmacology

authors： Gosho M,Maruo K,Tada K,Hirakawa A

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:The quality of drug therapy is an important issue for nursing homes. This study aimed to assess the prevalence of polypharmacy and potentially inappropriate medications (PIMs) in a large sample of nursing home residents by using the data recorded during the preparation of pill dispensers. METHODS:This is a cro...

journal_title：European journal of clinical pharmacology

authors： Herr M,Grondin H,Sanchez S,Armaingaud D,Blochet C,Vial A,Denormandie P,Ankri J

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:The aim of this study was to identify structure and language elements affecting the quality of responses from Scandinavian drug information centres (DICs). METHODS:Six different fictitious drug-related queries were sent to each of seven Scandinavian DICs. The centres were blinded for which queries were part of...

journal_title：European journal of clinical pharmacology

authors： Reppe LA,Spigset O,Kampmann JP,Damkier P,Christensen HR,Böttiger Y,Schjøtt J

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:We used a retrospective data mining approach to explore the association between serum amiodarone (AMD) and N-desethylamiodarone (DEA) concentrations and thyroid-related hormone levels. METHODS:Laboratory data sets from January 2012 to April 2016 were extracted from the computerized hospital information system ...

journal_title：European journal of clinical pharmacology

authors： Yamato M,Wada K,Fujimoto M,Hosomi K,Hayashi T,Oita A,Takada M

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:Intravenous (IV) magnesium sulfate (MgSO4) is used as adjunct therapy to treat acute asthma exacerbations. Despite its clinical use, there is a limited understanding of the disposition of magnesium in children. METHODS:To explore the pharmacokinetics (PK) of IV MgSO4 in this population, we collected retrospect...

journal_title：European journal of clinical pharmacology

authors： Rower JE,Liu X,Yu T,Mundorff M,Sherwin CM,Johnson MD

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:This study aimed to test the applicability and effectiveness of the principles and informed consent form (ICF) template proposed by the Strategic Initiative for Developing Capacity in Ethical Review (SIDCER) across multiple clinical trials involving Thai research participants with various conditions. METHODS:A...

journal_title：European journal of clinical pharmacology

authors： Koonrungsesomboon N,Tharavanij T,Phiphatpatthamaamphan K,Vilaichone RK,Manuwong S,Curry P,Siramolpiwat S,Punchaipornpon T,Kanitnate S,Tammachote N,Yamprasert R,Chanvimalueng W,Kaewkumpai R,Netanong S,Kitipawong P,Sritipsukh

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:The aim of the study was to compare plasma concentrations of rifampicin (RMP), isoniazid (INH) and pyrazinamide (PZA) between tuberculosis (TB) patients with and without diabetes mellitus (DM). METHODS:Two-hour post-dosing concentrations of RMP, INH and PZA were determined in adult TB patients that were studie...

journal_title：European journal of clinical pharmacology

authors： Kumar AK,Chandrasekaran V,Kannan T,Murali AL,Lavanya J,Sudha V,Swaminathan S,Ramachandran G

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Bosutinib is an oral, dual Src and Abl tyrosine kinase inhibitor (TKI) approved for the treatment of Philadelphia chromosome-positive chronic myeloid leukemia resistant or intolerant to prior TKI therapy. Bosutinib is primarily metabolized by cytochrome P450 (CYP) 3A4, suggesting drug interaction potential with...

journal_title：European journal of clinical pharmacology

authors： Hsyu PH,Pignataro DS,Matschke K

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:The aims of this study were to characterise the population pharmacokinetics of oxypurinol in patients receiving haemodialysis and to compare oxypurinol exposure in dialysis and non-dialysis patients. METHODS:Oxypurinol plasma concentrations from 6 gout people receiving haemodialysis and 19 people with gout not...

journal_title：European journal of clinical pharmacology

authors： Wright DF,Doogue MP,Barclay ML,Chapman PT,Cross NB,Irvine JH,Stamp LK

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:The use of estimated glomerular filtration rate (eGFR) in daily clinical practice. METHODS:eGFR is a key component in drug therapy management (DTM) in patients with renal impairment. eGFR is routinely reported by laboratories whenever a serum creatinine testing is ordered. In this paper, we will discuss how to...

journal_title：European journal of clinical pharmacology

authors： Eppenga WL,Kramers C,Derijks HJ,Wensing M,Wetzels JF,De Smet PA

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Visual hallucinations (VHs) are frequent non-motor complication of Parkinson's disease (PD), associated to a negative prognosis. Previous studies showed an association between dopamine receptor (DR) gene (DR) variants and psychosis in Alzheimer's disease, addictions, schizophrenia, and bipolar disorder. Howe...

journal_title：European journal of clinical pharmacology

authors： Ferrari M,Comi C,Marino F,Magistrelli L,De Marchi F,Cantello R,Riboldazzi G,Bono G,Cosentino M

更新日期：2016-11-01 00:00:00